The objective of calibration is to obtain a valid relationship between the signal produced by the analyte and the quantity of analyte in the standards used for calibration. ASI Standards recommends the matrix of the calibration standards and blank be matched to that of the sample matrix to compensate for matrix effects that influence the analytical response, a process also known as matrix matching.
Matrix effects are a major concern in most quantitative analysis because they detrimentally affect the accuracy, precision and sensitivity of a method. In X-ray fluorescence spectroscopy, matrix differences between the sample and standard matrix can lead to X-ray spectral responses that differ due to characteristic X-ray absorption, different
The standard addition method can be utilized to compensate for these matrix effects. Although effective, this method requires much more sample as the sample is needed for the calibration. This method is also more laborious and time consuming than external calibration methods. Advantages of standard addition method you should consider the issues. In order to avoid these issues, it is most convenient to have a blank and calibration standards that have a similar matrix to that of the sample matrix. ASI Standards specializes in creating custom standards so we are able to provide or create a matrix for your standards that is identical or that closely mimics that of your sample matrix to minimize matrix effect.
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Don’t see your matrix listed above? Please reach out to us. We can create a custom blend to match your samples matrix. We offer a variety of customizable reference materials and are always adapting to the market’s needs. For further information, or if you have questions about our products, please reach out to our sales and product development team at sales@asistandards.com