July 19, 2022

What is Matrix Matching and How is it Affecting Your Results?

The objective of calibration is to obtain a valid relationship between the signal produced by the analyte and the quantity of analyte in the standards used for calibration. ASI Standards recommends the matrix of the calibration standards and blank be matched to that of the sample matrix to compensate for matrix effects that influence the analytical response, a process also known as matrix matching.

Matrix effects are a major concern in most quantitative analysis because they detrimentally affect the accuracy, precision and sensitivity of a method. In X-ray fluorescence spectroscopy, matrix differences between the sample and standard matrix can lead to X-ray spectral responses that differ due to characteristic X-ray absorption, differentWhite Plain Tips for Successful Blog Instagram Post (2) amount of primary X-ray scattering as well as spectral line overlap. Also, not having matrix matched standards is one of the most significant factors affecting data quality for ICP-OES methods as matrix effects can influence spray chamber efficiency, plasma temperature, ionization efficiency, viscosity and more.

The standard addition method can be utilized to compensate for these matrix effects. Although effective, this method requires much more sample as the sample is needed for the calibration. This method is also more laborious and time consuming than external calibration methods. Advantages of standard addition method you should consider the issues. In order to avoid these issues, it is most convenient to have a blank and calibration standards that have a similar matrix to that of the sample matrix. ASI Standards specializes in creating custom standards so we are able to provide or create a matrix for your standards that is identical or that closely mimics that of your sample matrix to minimize matrix effect.

We can offer a variety of matrices over a range of ASTM methods. Some of our most common matrices include:


Oils Volatiles Solids
  • Mineral Oil: 4.5, 25, 75 cSt
  • Lubricating Oil: 25 cSt mineral oil with stabilizers used primarily for multielement standards
  • Diesel Fuel: Most commonly we sell a synthetic blend which is primarily mineral oil but matches diesel fuels density. The benefit of this synthetic blend is it is not considered dangerous goods and is cleaner than #2 diesel fuel. We can offer #2 diesel fuel if needed.
  • Crude Oil
  • Residual Oil
  • Gas Oil
  • Fuel Oil
  • Isooctane
  • Toluene
  • Xylenes: We can offer a single isomer of xylene (o, p, m)
  • Hexanes
  • Gasoline: We can also offer an isooctane/toluene mix to mimic gasoline matrix as this synthetic blend has lower sulfur and nitrogen impurities than pure gasoline.
  • Polyethylene
  • PVC
  • PET
  • Dried Paint: We offer lead in paint which is dried paint on a wooden block



Talk to Our Team If You Need a Custom Reference Material

Don’t see your matrix listed above? Please reach out to us. We can create a custom blend to match your samples matrix. We offer a variety of customizable reference materials and are always adapting to the market’s needs. For further information, or if you have questions about our products, please reach out to our sales and product development team at sales@asistandards.com

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